BHP leveraged on its experience on HIV surveillance to conduct COVID-19 genomic sequencing

Find out more about our ongoing and completed studies

Meet Dr Sikhulile Moyo, the Scientist who discovered Omicron at BHP Lab

Botswana Harvard AIDS Institute Partnership

A world-renowned educational institution of excellence in research and education pertinent to HIV/AIDS and other emerging public health challenges. Our mission is to fight HIV/AIDS and emerging public health challenges through innovative research, education, and capacity building that impact policy and practice.

Capacity Building

Research Papers

Ongoing Studies

Studies

Status : Ongoing

HPTN 084: A Phase 3 Double Blind Safety and Efficacy Study of Long-Acting Injectable Cabotegravir Compared to Daily Oral TDF/FTC for Pre-Exposure Prophylaxis in HIV-Uninfected Women

Status : Ongoing

HVTN 703/HPTN 081 (AMP Study): A phase 2b study to evaluate the efficacy of VRC01 broadly neutralizing monoclonal antibody in reducing acquisition of HIV-1 infection in women in Sub- Saharan Africa.

Status : Ongoing

HVTN805/HPTN093: Antiretroviral analytical treatment interruption (ATI) to assess immunologic and virologic responses in participants who initiated ART in early HIV infection after having received VRC01 or placebo in HVTN 703/HPTN 081.

Status : Ongoing

REPRIEVE (A5332): A randomized trial to prevent vascular events (such as stroke and heart attack) in people living with HIV.

Status : Completed

Potlako: A programmatic Multi-Facility Level Intervention to Improve Access to timely Oncology Care in Botswana

Status : Ongoing

PHOENIx (A5300B): Protecting Households on Exposure to Newly Diagnosed Index Multidrug Resistant TB patients

Status : Ongoing

IMPAACT 2019 – Phase I/II Study of the Pharmacokinetics, Safety, and Tolerability of Abacavir/Dolutegravir/Lamivudine Dispersible and Immediate Release Tablets in HIV-1-Infected Children Less than 12 Years of Age

Status : Ongoing

P1093 - Phase I/II, Multi-Centre, Open-Label Pharmacokinetic, Safety, Tolerability and Antiviral Activity of Dolutegravir, a Novel Integrase Inhibitor, in Combination Regimens in HIV-1 Infected Infants, Children and Adolescents

Status : Ongoing

Status : Ongoing

IMPAACT 2017 - Phase I/II Study of the Safety, Acceptability, Tolerability, and Pharmacokinetics of Oral and Long-Acting Injectable Cabotegravir and Long-Acting Injectable Rilpivirine in Virologically Suppressed HIV-Infected Children and Adolescents

Status : Ongoing

CoVPN 5001: A Prospective Study of Acute Immune Responses to SARS-CoV-2 Infection.

Status : Ongoing

Birth Outcomes Surveillance Study: Tsepamo Study

Status : Ongoing

Early Infant Treatment Study: A Clinical Trial of HIV Positive Infants in Botswana

Status : Ongoing

Tshilo Dikotla Study: Metabolic Outcomes of Children HIV/ARV- Exposed Uninfected in Botswana

Status : Ongoing

Karabo Study: Immune Correlates of Tuberculosis and non-Tuberculosis Infectious Morbidity in Southern African HIV- Exposed, Uninfected Infants

Status : Ongoing

FLOURISH: Following Longitudinal Outcomes to Understand, Report, Intervene and Sustain Health for Infants, Children, Adolescents who are HIV Exposed Uninfected

Status : Ongoing

Feasibility and Accuracy of Nanosenor-based cancer diagnosis at the point of care (Chedza Study).

Status : Ongoing

Characterization of Anthracycline induced Cardiotoxicity Using Cardiac Magnetic Resonance in Botswana: A Prospective Observational study (Pelo Study)

Status : Ongoing

HIV and Malignancy in Botswana: An observational Study of Medicine Toxicity of Concurrent Treatment and Clinical Outcomes (Thabatse Study)

Status : Ongoing

Potlako+ : A multilevel intervention to improve timely cancer detection and treatment initiation in Botswana

Status : Ongoing

Human Papillomavirus (HPV) Cervical Cancer Screening Study

Status : Ongoing

The diagnosis and treatment of Chlamydia Trachomatis and Neisseria Gonorrhea in Woman to prevent adverse neonatal consequences (Maduo/STI Study)

Status : Ongoing

Contraceptives and Dolutegravir-based ART (CODA) Study

Status : Ongoing

Albuminuria Among Virally Suppressed HIV-infected Patients in Botswana: Longitudinal Changes and Association with Inflammation and ACEI/ARB Use in a Clinical Setting - Albuminuria Study

Status : Ongoing

Mopati: A Pilot HIV Treatment Partner Intervention in Botswana

Status : Ongoing

Exploring the Acceptability and Feasibility of COVID19 Testing among Truck Drivers in Botswana

Status : Ongoing

Innovative HIV Testing Strategy for Middle-to-Upper Income Men in a Resource-Limited Setting

Status : Ongoing

Integrating Hypertension and Cardiovascular Diseases Care into Existing HIV Services Package in Botswana (InterCARE Study)

Status : Ongoing

Prevalence and outcomes of the usage of lumbar puncture in patients who presented with central nervous system symptoms at Princess Marina Hospital during the period 01/01/2014 to 31/03/2021

Status : Ongoing

A cross-sectional evaluation of antibody responses to SARS-COV-2 vaccines

Status : Ongoing

Multi-Center, Randomized, Efficacy Study of COVID-19 mRNA Vaccine in Regions with SARS-CoV-2 Variants of Concern: CoVPN 3008

Status : Ongoing

Mitigating the impact of COVID-19 effects in adolescent reproductive health through self-testing: a mixed methods pilot study: “ICHEKE”

Status : Ongoing

International Sexual Health and Reproductive (ISHARE) Health Survey During COVID-19

Status : Ongoing

Assessment of proviral reservoir: synergistic combination of reporter cell assay and viral diversity

Status : Ongoing

Understanding the Mechanisms of Adverse Birth Outcomes in Botswana

Status : Ongoing

SOLIDARITY Trial: An international (multisite)randomized trial of additional treatments for COVID-19 in hospitalized patients who are all receiving the local standard of care

Status : Ongoing

Open-label access to dolutegravir for HIV-1 infected children and adolescents completing IMPAACT Studies P1093 and P2019: GSK205858

Status : Ongoing

Assessing barriers and facilitators to improving prenatal supplementation and preconception fortification in Botswana – a qualitative study

Status : Ongoing

Open-Label, Single-Arm, Phase 3B Study of the Incidence of Severe COVID-19 and Adverse Events Following AZD1222 COVID-19 Vaccination in Botswana Against SARS-CoV-2

Status : Completed

COVID-19: An observational cohort of cases treated in Gaborone, Botswana

Status : Completed

Botswana Combination Prevention Project (BCPP) / Ya Tsie Study

Status : Completed

IMPAACT 2008: A Phase I/II Multisite, Randomized, Controlled Study of Monoclonal Antibody VRC01 with Combination Antiretroviral Therapy to Promote Clearance of HIV-1-Infected Cells in Infants

Status : Completed

IMPAACT 2010: IMPAACT 2010 Phase III Study of the Virologic Efficacy and Safety of Dolutegravir-Containing versus Efavirenz-Containing Antiretroviral Therapy Regimens in HIV-1-Infected Pregnant Women and their Infants

Status : Completed

IMPAACT P1026s: Pharmacokinetic Properties of Antiretroviral And Related Drugs During Pregnancy And Postpartum

Status : Completed

Effects of preterm birth on HIV acquisition risk and antiretroviral prophylaxis in HIV-exposed infants in Botswana (PERHAPS)

Status : Completed

The AMBIsome Therapy Induction OptimisatioN (AMBITION-cm)

Status : Completed

Assessing the potential role of a novel hand-held device (the Intelligent Breast Exam), in breast cancer screening in Botswana: A feasibility pilot study

Status : Completed

Kgothatso: Male cancer care barriers in Botswana

Status : Completed

Innovating to save lives: Evaluation of breast cancer care and outcomes in the setting of Breast multidisciplinary clinic in Botswana (Maduo Study)

Status : Completed

Acceptability and uptake of HIV self-testing among female sex workers in Botswana: Ikitse Study

Status : Completed

Botswana COVID-19 Active Case Finding Pilot Study and Demonstration Project

Status : Completed

The Lived Experience of Participants in COVID-19 Clinical Studies in Gaborone– World Health Organisation (WHO)

Status : Completed

A5375: An Open-Label, Phase II Pharmacokinetic Study to Evaluate Double-Dose Levonorgestrel Emergency Contraception in Combination with Efavirenz-Based Antiretroviral Therapy or Rifampicin-Containing Anti-Tuberculosis Therapy

Status : Completed

Optimizing Maternal & Child Health and Development (Monana Ke Isago Study)

Status : Completed

A Clinical Trial to Evaluate the Impact of Broadly Neutralizing Antibodies VRC01LS and 10-1074 on Maintenance of HIV Suppression in a Cohort of Early-Treated Children in Botswana (Dual bNAb Treatment in Children)/ Tatelo Study

Status : Ongoing

Neurodevelopment In HEU Children Exposed In Utero To Dolutegravir or Efavirenz and HIV-Unexposed Children (Motheo Study)

Status : Completed

A Randomized Study of Cotrimoxazole Prophylaxis and Longer Breastfeeding Duration to Improve Survival Among HIV-Exposed Infants in Botswana ("Mpepu")

Status : Completed

Prevention of Milk-Borne Transmission of HIV-1 in Botswana (“Mashi”)

Status : Completed

Virologic Response to NVP-Containing HAART after Single-DoseNVP vs.Placebo (“Mashi Plus”)

Status : Completed

Randomized Trial of LPV/r/ZDV3TC vs. ABC/ZDV/3TC to Prevent MTCT in Pregnant/Breastfeeding Women with CD4>200 (“MmaBana”)

Status : Completed

Effects of HIV and ARV Exposure on Child Health and Neurodevelopment, Botswana (“Tshipidi”)

Status : Ongoing

Post-acute sequelae of SARS-CoV-2 infection (PASC) / ‘Long Covid’: observational cohort: “Motlhala” Study

Media

May 06, 2022

Spotlighting Emily Makunike-Shava, MBChB, Msc: Q&A

Passengers register their information on arrival at Sir Seretse Khama International Airport in Gaborone, Botswana, June 3, 2020. Xinhua via Getty/Photo by Tshekiso Tebalo

April 13, 2022

Inside The Lab That Identified Omicron

BHP Board Chairman and Principal Investigator for Tatelo Study presenting study findings at the Ministry of Health

March 31, 2022

Dual bNAb HIV Treatment Well Tolerated In Children

Tsepamo Study Coordinator, Modiegi Diseko updating the Ministry of Health and Wellness on study progress

March 31, 2022

BHP Updates MOHW on Tsepamo Study Progress

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