Study Objectives: The overall aim of this study is to determine the feasibility, utility and yield of COVID-19 case finding strategies in Botswana, and generate data to guide the effective implementation of COVID-19 case finding in Botswana. Specifically we will evaluate three different testing strategies for COVID-19: 

Objective 1: Point of Entry Screening and Testing 
Objective 2: Enhanced Healthcare Facility Based Screening and Testing 
Objective 3: Active Community Case Finding 

Study Design: A pilot surveillance study 

Study Population and Size: 

Objective 1: All individuals, regardless of age, transporting essential goods or goods vehicles across the land borders at the specified locations. 

Objective 2: All individuals, regardless of age, who meet the COVID-19 suspected case definition presenting to or already admitted to the stated healthcare facilities. 

Objective 3: All individuals, regardless of age, who meet the COVID-19 suspected case definition. 

Across all three objectives, consecutively eligible individuals will be tested. No formal sample size calculation is required for this active case finding pilot.
 
Objective 1: We anticipate approximately 400 arrivals per day across the six borders. Over the course of three months this totals approximately 36,000 participants. At present the only cross border traffic permitted are individuals delivering essential goods. Any returning residents not delivering goods are required to undertake a mandatory two-week period of institutional quarantine and are not the target of this study. 

Objective 2: Projected numbers are difficult to estimate given a lack of available data. We anticipate approximately 100 tests per day across the six sites. Over the course of a three month period this totals to approximately 9,000 tests. 

Objective 3: Projected numbers are difficult to estimate given a lack of available data. We anticipate approximately 60 tests per day across the two areas. Over the course of a three month period this totals to approximately 5,400 tests. The overall estimated number of tests is therefore approximately 50,400. 

Study Duration: 6 months

Study Results: Sponsor: Center for Disease Control and Prevention (CDC).