The Botswana Epidemiological ART Treatment Cohort Study 2 (2TheBEAT Cohort Study)

Principal Investigator: Ava Avalos, MD

Study Objectives

Primary Objectives

A Clinical Trial to Evaluate the Impact of Broadly Neutralizing Antibodies VRC01LS and 10-1074 on Maintenance of HIV Suppression in a Cohort of Early-Treated Children in Botswana (Dual bNAb Treatment in Children)/ Tatelo Study
Principal Investigator Initiated

Study Objectives:

A cross-sectional evaluation of antibody responses to SARS-COV-2 vaccines
Principal Investigator Initiated

Principal Investigator - Professor Mosepele Mosepele MD, MSc

Study Objectives

Primary Objectives:

  1. To evaluate SARS-CoV-2-specific qualitative antibody responses after the administration of full vaccination doses (either single or second doses) of vaccines in Botswana.
  2. To evaluate SARS-CoV-2-specific quantitative antibody responses after the administration of full doses of vaccines in Botswana.

Secondary Objectives:

Albuminuria Among Virally Suppressed HIV-infected Patients in Botswana: Longitudinal Changes and Association with Inflammation and ACEI/ARB Use in a Clinical Setting - Albuminuria Study
Principal Investigator Initiated

Principal Investigator - Professor Mosepele Mosepele, MD, MSc

Study Status: The study opened on January 22, 2020 and accrual completed on January 27, 2021. Participant follow up ongoing.

Study Objectives:

Assessment of Proviral Reservoir: Synergistic combination of reporter cell assay and viral diversity
Principal Investigator Initiated

Principal Investigators - Dr. Sikhulile Moyo, MSc, MPH, PhD | Dr. Catherine K. Koofhethile, PhD

Study Objectives:  This study has two main goals:

Birth Outcomes Surveillance Study: Tsepamo Study
Principal Investigator Initiated

Principal Investigator - Professor Roger L. Shapiro, MD, MPH

Study Objectives

Primary Objectives

Botswana Safe Birth Study
Principal Investigator Initiated

Principal Investigator: Rebecca Luckett MD MPH

Study Objectives

Objective 1: Improve the quality of decision making around caesarean section

Cellular and humoral immune response in HIV-1-infected children receiving SARS-CoV2-specific mRNA vaccines in Botswana
Principal Investigator Initiated

Principal Investigator: Catherine Koofhethile, PhD and Mathias Lichterfeld, PhD

Study Objectives:

To assess cellular and humoral immune responses in HIV-1-infected children and teenagers receiving SARS-CoV2-specific mRNA vaccines in Botswana.

Characterization of Anthracycline induced Cardiotoxicity Using Cardiac Magnetic Resonance in Botswana: A Prospective Observational study (Pelo Study)
Principal Investigator Initiated

Principal Investigator - Dr. Scott Dryden-Peterson MD, MSc

Study Objectives

Aim 1: The study will compare the LVEF between patients with and without HIV  who are being treated with anthracyclines. We hypothesize that the LVEF will be  lower after anthracycline among individuals living with HIV.

Cognitive Testing of a survey instrument to assess sexual practices, behaviours, and health-related outcomes
Principal Investigator Initiated

Principal Investigator: Chelsea Morroni, MPH, MPhil, PhD, MBChB, DTM&H, DFSRH

Study Objectives:

Contraceptives and Dolutegravir-based ART (CODA) Study
Principal Investigator Initiated

Principal Investigator - Dr. Chelsea Morroni, MD, MPH, PhD

Name of the Study: The Contraceptives and Dolutegravir-based ART (CODA) Study

Study Status: Recruiting 

Study Objectives:

Doris Duke Study: Adverse Cardiometabolic Impact of Antiretroviral Treatment Regimens Among Pregnant and Post-Partum Women and Their Infants
Principal Investigator Initiated

Principal Investigator: Rebecca Zash, MD

Study Objectives:

Primary objectives

Dual HIV/syphilis point-of-care testing to improve identification and treatment of syphilis among pregnant women in Gaborone, Botswana
Principal Investigator Initiated

Study Objectives: To determine the acceptability, feasibility, and costs of implementing point-of-care syphilis testing and treatment among pregnant women in Gaborone, Botswana.

Study Design: Cohort study

DYNAMICS OF HIV-1 IN RECENTLY DIAGNOSED INDIVIDUALS IN BOTSWANA IN THE ERA OF “TREAT ALL”
Principal Investigator Initiated

Principal Investigator: Natasha Onalenna Moraka

Study Objectives:

General Aim

This study aims to study the viral dynamics of recently diagnosed people living with HIV in the era of “Treat all” in Botswana.

Early Infant Treatment Study: A Clinical Trial of HIV Positive Infants in Botswana
Principal Investigator Initiated

Principal Investigator - Professor Roger L. Shapiro, MD, MPH

Study Objectives

The overall objective of the EIT study is to determine whether very early antiretroviral treatment (ART) initiation in HIV-infected infants limits the seeding of viral reservoirs and maintains immune responses, potentially allowing future periods off ART.

Specific Aims: 

Evaluating Opportunities to Improve TB and HIV Care for Adolescents in Botswana
Principal Investigator Initiated

Study Objectives

Evaluation of pregnant and breastfeeding women’s preferences and attitudes towards long-acting pre-exposure prophylaxis: A discrete choice experiment. MERCK
Principal Investigator Initiated

Principal Investigator: Chelsea Morroni, MPH, MPhil, PhD, MBChB, DTM&H, DFSRH

Study Objectives:

Objective 1

Experiences of Infant Feeding Decision-Making among Mothers Living with and without HIV in Botswana
Principal Investigator Initiated

Principal Investigator: Roxanna Haghighat, DPhil | Kathleen Powis, MD, MPH, MBA

Study Objectives

Exploring the Acceptability and Feasibility of COVID19 Testing among Truck Drivers in Botswana
Principal Investigator Initiated

Principal Investigator - Nabila Youssouf PhD | Laura Bogart | Mosepele Mosepele MD, MSc

Name of the Study: Exploring the Acceptability and Feasibility of COVID19 Testing among Truck Drivers in Botswana

Study Status: Completed recruitment – data analysis ongoing

Study Objectives: To explore the acceptability and feasibility on COVID 19 testing among truck drivers entering Botswana and to acquire feedback about potential interventions to further respond to this evolving crisis. 

Feasibility and Accuracy of Nanosenor-based cancer diagnosis at the point of care (Chedza Study).
Principal Investigator Initiated

Principal Investigator - Dr. Scott Dryden-Peterson, MD, MSc