Study You Wish to Participate - None -Point-of-Care HIV Testing and Early Dolutegravir Use for Infants (Moso Study)Assessment of Proviral Reservoir: Sub study to determine the role of the immune system on the reservoir.Early Infant Treatment Study: A Clinical Trial of HIV Positive Infants in BotswanaAssessment of Proviral Reservoir: Synergistic combination of reporter cell assay and viral diversityA Clinical Trial to Evaluate the Impact of Broadly Neutralizing Antibodies VRC01LS and 10-1074 on Maintenance of HIV Suppression in a Cohort of Early-Treated Children in Botswana (Dual bNAb Treatment in Children)/ Tatelo StudyIMPAACT 2042: Phase I/II Trial to Evaluate the Impact of Three Broadly Neutralizing Antibodies or Analytic Treatment Interruption on Viral Reservoir, Immune Function, and Maintenance of HIV Suppression in Early-Treated Children in BotswanaEquitable access to care for migrants living with HIV in Southern Africa: Lessons learnt from Botswana’s migrant inclusive programHPV Screening and Management Strategies Utilizing Extended Molecular HPV DNA Genotyping and Viral Load in Women Living with HIVA Phase I, Randomized, Placebo-Controlled Study of the Safety, Antiviral & Immunomodulatory Activity of Broadly Neutralizing Antibodies 3BNC117-LS-J and 10-1074-LS-J in Combination in ART-treated Adults in sub-Saharan Africa Living with HIV during a MonitLong-Term Follow-Up of CAB LA for Participants in HPTN 083 and HPTN 084 CAB PrEP Studies at Risk of HIV AcquisitionEfficacy of Human Papillomavirus (HPV) Vaccination to Prevent Infection Among Women Living with HIV: A Prospective, Individual, Double-Blind, Randomized Controlled Study (HOPE-II)Genomic epidemiology of Treponema pallidum in South Africa and BotswanaA Phase 4, Open-Label, Rollover Study to Provide Continued Access to Cabotegravir Long-acting Injection and Rilpivirine Long-acting Injection to Participants Living with Human Immunodeficiency Virus Type 1 (HIV-1) Infection Who Participated in Long-actingA Randomized, Double-Blinded, Placebo-Controlled Study of the Combination of Two Long-Acting Broadley Neutralizing Antibodies at ART Initiation in Adults Living With HIV-1 in Sub-Saharan Africa (version 1.0 July 20,2023 for site 12701)Aspirin, antenatal micronutrients, and azithromycin (AAA) trial for maximal reduction of preterm birth and related outcomesBirth Outcomes Surveillance Study: Tsepamo StudyMotsepe Wastewater ProjectVirologic responses among people with HIV on dolutegravir-based first line therapy in BotswanaDYNAMICS OF HIV-1 IN RECENTLY DIAGNOSED INDIVIDUALS IN BOTSWANA IN THE ERA OF “TREAT ALL”Linking HIV Prevention and Postpartum Care: Safety, Efficacy and Feasibility of Cabotegravir-LA PrEP in a High-Risk Breastfeeding Population in Botswana (Tshireletso Study)Evaluating a Group-Based Intervention to Improve Mental Health and ART Adherence Among Youth Living with HIV in Low Resource Settings (IMPAACT 2016)Virologic and Molecular characterization of HIV-1Strains in non-citizens in BotswanaThe FACET Study: Family Dynamics and Child Neurodevelopment in BotswanaSafety, Tolerability, and Impact of Oral TLR8 Agonist Selgantolimod on HBsAg in Participants with Both Chronic Hepatitis B and HIV; v1.0 May 27, 2022; IND #158394; Site 12701/GaboronePRomoting Equity for Pregnant Adolescents in REsearch (PREPARE) in BotswanaPost abortion care in Botswana: Impact of HIV status on outcomesEvaluation of pregnant and breastfeeding women’s preferences and attitudes towards long-acting pre-exposure prophylaxis: A discrete choice experiment. MERCKMulti-Country Aetiology of Genital Ulcer Study (MAGUS)Doris Duke Study: Adverse Cardiometabolic Impact of Antiretroviral Treatment Regimens Among Pregnant and Post-Partum Women and Their InfantsPhase I/II Study of the Safety, Tolerability, Acceptability, and Pharmacokinetics of Oral and Long-Acting Injectable Cabotegravir and Rilpivirine in Virologically Suppressed Children Living with HIV-1, Two to Less Than 12 Years of Age Cognitive Testing of a survey instrument to assess sexual practices, behaviours, and health-related outcomesCellular and humoral immune response in HIV-1-infected children receiving SARS-CoV2-specific mRNA vaccines in BotswanaIn Country Evaluation for the ANC panelExperiences of Infant Feeding Decision-Making among Mothers Living with and without HIV in BotswanaSingle, High-dose AmBisome to Reduce Excess mortality from Cryptococcal Meningitis (SHARE-CM)IMPRINT NIHR Global Health Research GroupDual HIV/syphilis point-of-care testing to improve identification and treatment of syphilis among pregnant women in Gaborone, BotswanaThe diagnosis and treatment of Chlamydia trachomatis and Neisseria gonorrhoeae in pregnant women to prevent adverse neonatal consequences.Iron and Folic acid supplimentation and adverse birth outcomes in BotswanaThe Botswana Epidemiological ART Treatment Cohort Study 2 (2TheBEAT Cohort Study) Botswana Safe Birth StudyIncreasing Access to Multiple Micronutrient Supplementation – A Pilot Intervention at up to 15 Clinics in Botswana Evaluating Opportunities to Improve TB and HIV Care for Adolescents in BotswanaPoint-of-Care HIV Testing and Early Dolutegravir Use for InfantsImproving TB Screening in Pregnant and Postpartum Women Living with HIV in BotswanaP1093 - Phase I/II, Multi-Centre, Open-Label Pharmacokinetic, Safety, Tolerability and Antiviral Activity of Dolutegravir, a Novel Integrase Inhibitor, in Combination Regimens in HIV-1 Infected Infants, Children and AdolescentsIMPAACT 2019 – Phase I/II Study of the Pharmacokinetics, Safety, and Tolerability of Abacavir/Dolutegravir/Lamivudine Dispersible and Immediate Release Tablets in HIV-1-Infected Children Less than 12 Years of AgeIMPAACT 2005IMPAACT 2017 - Phase I/II Study of the Safety, Acceptability, Tolerability, and Pharmacokinetics of Oral and Long-Acting Injectable Cabotegravir and Long-Acting Injectable Rilpivirine in Virologically Suppressed HIV-Infected Children and AdolescentsHVTN805/HPTN093: Antiretroviral analytical treatment interruption (ATI) to assess immunologic and virologic responses in participants who initiated ART in early HIV infection after having received VRC01 or placebo in HVTN 703/HPTN 081.PHOENIx (A5300B): Protecting Households on Exposure to Newly Diagnosed Index Multidrug Resistant TB patientsREPRIEVE (A5332): A randomized trial to prevent vascular events (such as stroke and heart attack) in people living with HIV.HVTN 703/HPTN 081 (AMP Study): A phase 2b study to evaluate the efficacy of VRC01 broadly neutralizing monoclonal antibody in reducing acquisition of HIV-1 infection in women in Sub- Saharan Africa.CoVPN 5001: A Prospective Study of Acute Immune Responses to SARS-CoV-2 Infection.Multi-Center, Randomized, Efficacy Study of COVID-19 mRNA Vaccine in Regions with SARS-CoV-2 Variants of Concern: CoVPN 3008Open-Label, Single-Arm, Phase 3B Study of the Incidence of Severe COVID-19 and Adverse Events Following AZD1222 COVID-19 Vaccination in Botswana Against SARS-CoV-2HPTN 084: A Phase 3 Double Blind Safety and Efficacy Study of Long-Acting Injectable Cabotegravir Compared to Daily Oral TDF/FTC for Pre-Exposure Prophylaxis in HIV-Uninfected WomenInternational Sexual Health and Reproductive (ISHARE) Health Survey During COVID-19Understanding the Mechanisms of Adverse Birth Outcomes in BotswanaSOLIDARITY Trial: An international (multisite)randomized trial of additional treatments for COVID-19 in hospitalized patients who are all receiving the local standard of careA cross-sectional evaluation of antibody responses to SARS-COV-2 vaccinesIntegrating Hypertension and Cardiovascular Diseases Care into Existing HIV Services Package in Botswana (InterCARE Study)HIV and Malignancy in Botswana: An observational Study of Medicine Toxicity of Concurrent Treatment and Clinical Outcomes (Thabatse Study)Exploring the Acceptability and Feasibility of COVID19 Testing among Truck Drivers in BotswanaCharacterization of Anthracycline induced Cardiotoxicity Using Cardiac Magnetic Resonance in Botswana: A Prospective Observational study (Pelo Study)Feasibility and Accuracy of Nanosenor-based cancer diagnosis at the point of care (Chedza Study).Prevalence and outcomes of the usage of lumbar puncture in patients who presented with central nervous system symptoms at Princess Marina Hospital during the period 01/01/2014 to 31/03/2021Mitigating the impact of COVID-19 effects in adolescent reproductive health through self-testing: a mixed methods pilot study: “ICHEKE”Open-label access to dolutegravir for HIV-1 infected children and adolescents completing IMPAACT Studies P1093 and P2019: GSK205858Post-acute sequelae of SARS-CoV-2 infection (PASC) / ‘Long Covid’: observational cohort: “Motlhala” StudyNeurodevelopment In HEU Children Exposed In Utero To Dolutegravir or Efavirenz and HIV-Unexposed Children (Motheo Study)Innovative HIV Testing Strategy for Middle-to-Upper Income Men in a Resource-Limited SettingThe diagnosis and treatment of Chlamydia Trachomatis and Neisseria Gonorrhea in Woman to prevent adverse neonatal consequences (Maduo/STI Study)Contraceptives and Dolutegravir-based ART (CODA) StudyHuman Papillomavirus (HPV) Cervical Cancer Screening StudyKarabo Study: Immune Correlates of Tuberculosis and non-Tuberculosis Infectious Morbidity in Southern African HIV- Exposed, Uninfected InfantsTshilo Dikotla Study: Metabolic Outcomes of Children HIV/ARV- Exposed Uninfected in BotswanaPotlako+ : A multilevel intervention to improve timely cancer detection and treatment initiation in BotswanaFLOURISH: Following Longitudinal Outcomes to Understand, Report, Intervene and Sustain Health for Infants, Children, Adolescents who are HIV Exposed UninfectedMopati: A Pilot HIV Treatment Partner Intervention in BotswanaAlbuminuria Among Virally Suppressed HIV-infected Patients in Botswana: Longitudinal Changes and Association with Inflammation and ACEI/ARB Use in a Clinical Setting - Albuminuria StudyAssessing barriers and facilitators to improving prenatal supplementation and preconception fortification in Botswana – a qualitative study
