Study Objectives

1. Compare weight gain and dietary intake, blood pressure and hypoglycaemia in pregnancy and through 18 months post-partum among women living with HIV on DTG compared with women on EFV and women without HIV.
2. Evaluate the impact of weight gain and dietary intake on adverse birth outcomes (preterm delivery, small for gestational age (SGA), and neonatal death) and child growth through 18 months of age.

Study Design

This prospective cohort study will enrol women admitted to maternity after delivery and prospectively follow woman-infant pairs from time to 18 months post-partum using both phone call and in person visits.

Study Population and Size

The study will include 900 post-partum women with and without HIV.  Among women with HIV, some will be on dolutegravir (DTG)-based ART and some will be on efavirenz (EFV)-based ART

Study Duration: 36 months

Sponsor: Doris Duke Charitable Foundation (DDCF)

Principal Investigator: Dr Rebecca Zash