Botswana Harvard Health Partnership

A world-renowned educational institution of excellence in research and education pertinent to HIV/AIDS and other emerging public health challenges. Our mission is to fight HIV/AIDS and emerging public health challenges through innovative research, education, and capacity building that impact policy and practice.

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Capacity Building
research
Research Papers
Ongoing
Ongoing Studies

Studies

Status : Ongoing

Assessing barriers and facilitators to improving prenatal supplementation and preconception fortification in Botswana – a qualitative study
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Status : Ongoing

Albuminuria Among Virally Suppressed HIV-infected Patients in Botswana: Longitudinal Changes and Association with Inflammation and ACEI/ARB Use in a Clinical Setting - Albuminuria Study
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Status : Ongoing

Mopati: A Pilot HIV Treatment Partner Intervention in Botswana
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Status : Ongoing

FLOURISH: Following Longitudinal Outcomes to Understand, Report, Intervene and Sustain Health for Infants, Children, Adolescents who are HIV Exposed Uninfected
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Status : Ongoing

Potlako+ : A multilevel intervention to improve timely cancer detection and treatment initiation in Botswana
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Status : Ongoing

Tshilo Dikotla Study: Metabolic Outcomes of Children HIV/ARV- Exposed Uninfected in Botswana
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Status : Ongoing

Karabo Study: Immune Correlates of Tuberculosis and non-Tuberculosis Infectious Morbidity in Southern African HIV- Exposed, Uninfected Infants
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Status : Ongoing

Human Papillomavirus (HPV) Cervical Cancer Screening Study
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Status : Ongoing

Contraceptives and Dolutegravir-based ART (CODA) Study
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Status : Ongoing

The diagnosis and treatment of Chlamydia Trachomatis and Neisseria Gonorrhea in Woman to prevent adverse neonatal consequences (Maduo/STI Study)
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Status : Ongoing

Innovative HIV Testing Strategy for Middle-to-Upper Income Men in a Resource-Limited Setting
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Status : Ongoing

Neurodevelopment In HEU Children Exposed In Utero To Dolutegravir or Efavirenz and HIV-Unexposed Children (Motheo Study)
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Status : Ongoing

Post-acute sequelae of SARS-CoV-2 infection (PASC) / ‘Long Covid’: observational cohort: “Motlhala” Study
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Status : Ongoing

Open-label access to dolutegravir for HIV-1 infected children and adolescents completing IMPAACT Studies P1093 and P2019: GSK205858
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Status : Ongoing

Mitigating the impact of COVID-19 effects in adolescent reproductive health through self-testing: a mixed methods pilot study: “ICHEKE”
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Status : Ongoing

Prevalence and outcomes of the usage of lumbar puncture in patients who presented with central nervous system symptoms at Princess Marina Hospital during the period 01/01/2014 to 31/03/2021
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Status : Ongoing

Feasibility and Accuracy of Nanosenor-based cancer diagnosis at the point of care (Chedza Study).
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Status : Ongoing

Characterization of Anthracycline induced Cardiotoxicity Using Cardiac Magnetic Resonance in Botswana: A Prospective Observational study (Pelo Study)
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Status : Ongoing

Exploring the Acceptability and Feasibility of COVID19 Testing among Truck Drivers in Botswana
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Status : Ongoing

HIV and Malignancy in Botswana: An observational Study of Medicine Toxicity of Concurrent Treatment and Clinical Outcomes (Thabatse Study)
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Status : Ongoing

Integrating Hypertension and Cardiovascular Diseases Care into Existing HIV Services Package in Botswana (InterCARE Study)
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Status : Ongoing

A cross-sectional evaluation of antibody responses to SARS-COV-2 vaccines
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Status : Ongoing

SOLIDARITY Trial: An international (multisite)randomized trial of additional treatments for COVID-19 in hospitalized patients who are all receiving the local standard of care
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Status : Ongoing

Understanding the Mechanisms of Adverse Birth Outcomes in Botswana
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Status : Ongoing

International Sexual Health and Reproductive (ISHARE) Health Survey During COVID-19
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Status : Ongoing

HPTN 084: A Phase 3 Double Blind Safety and Efficacy Study of Long-Acting Injectable Cabotegravir Compared to Daily Oral TDF/FTC for Pre-Exposure Prophylaxis in HIV-Uninfected Women
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Status : Ongoing

Open-Label, Single-Arm, Phase 3B Study of the Incidence of Severe COVID-19 and Adverse Events Following AZD1222 COVID-19 Vaccination in Botswana Against SARS-CoV-2
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Status : Ongoing

Multi-Center, Randomized, Efficacy Study of COVID-19 mRNA Vaccine in Regions with SARS-CoV-2 Variants of Concern: CoVPN 3008
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Status : Ongoing

CoVPN 5001: A Prospective Study of Acute Immune Responses to SARS-CoV-2 Infection.
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Status : Ongoing

HVTN 703/HPTN 081 (AMP Study): A phase 2b study to evaluate the efficacy of VRC01 broadly neutralizing monoclonal antibody in reducing acquisition of HIV-1 infection in women in Sub- Saharan Africa.
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Status : Ongoing

REPRIEVE (A5332): A randomized trial to prevent vascular events (such as stroke and heart attack) in people living with HIV.
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Status : Ongoing

PHOENIx (A5300B): Protecting Households on Exposure to Newly Diagnosed Index Multidrug Resistant TB patients
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Status : Ongoing

HVTN805/HPTN093: Antiretroviral analytical treatment interruption (ATI) to assess immunologic and virologic responses in participants who initiated ART in early HIV infection after having received VRC01 or placebo in HVTN 703/HPTN 081.
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Status : Ongoing

IMPAACT 2017 - Phase I/II Study of the Safety, Acceptability, Tolerability, and Pharmacokinetics of Oral and Long-Acting Injectable Cabotegravir and Long-Acting Injectable Rilpivirine in Virologically Suppressed HIV-Infected Children and Adolescents
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Status : Ongoing

IMPAACT 2005
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Status : Ongoing

IMPAACT 2019 – Phase I/II Study of the Pharmacokinetics, Safety, and Tolerability of Abacavir/Dolutegravir/Lamivudine Dispersible and Immediate Release Tablets in HIV-1-Infected Children Less than 12 Years of Age
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Status : Completed

A Randomized Study of Cotrimoxazole Prophylaxis and Longer Breastfeeding Duration to Improve Survival Among HIV-Exposed Infants in Botswana ("Mpepu")
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Status : Completed

Virologic Response to NVP-Containing HAART after Single-DoseNVP vs.Placebo (“Mashi Plus”)
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Status : Completed

Prevention of Milk-Borne Transmission of HIV-1 in Botswana (“Mashi”)
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Status : Completed

Randomized Trial of LPV/r/ZDV3TC vs. ABC/ZDV/3TC to Prevent MTCT in Pregnant/Breastfeeding Women with CD4>200 (“MmaBana”)
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Status : Completed

Effects of HIV and ARV Exposure on Child Health and Neurodevelopment, Botswana (“Tshipidi”)
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Status : Completed

A5375: An Open-Label, Phase II Pharmacokinetic Study to Evaluate Double-Dose Levonorgestrel Emergency Contraception in Combination with Efavirenz-Based Antiretroviral Therapy or Rifampicin-Containing Anti-Tuberculosis Therapy
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Status : Completed

The Lived Experience of Participants in COVID-19 Clinical Studies in Gaborone– World Health Organisation (WHO)
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Status : Completed

Acceptability and uptake of HIV self-testing among female sex workers in Botswana: Ikitse Study
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Status : Completed

Innovating to save lives: Evaluation of breast cancer care and outcomes in the setting of Breast multidisciplinary clinic in Botswana (Maduo Study)
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Status : Completed

Botswana COVID-19 Active Case Finding Pilot Study and Demonstration Project
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Status : Completed

Kgothatso: Male cancer care barriers in Botswana
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Status : Completed

Assessing the potential role of a novel hand-held device (the Intelligent Breast Exam), in breast cancer screening in Botswana: A feasibility pilot study
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Status : Completed

The AMBIsome Therapy Induction OptimisatioN (AMBITION-cm)
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Status : Completed

Effects of preterm birth on HIV acquisition risk and antiretroviral prophylaxis in HIV-exposed infants in Botswana (PERHAPS)
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Status : Completed

IMPAACT P1026s: Pharmacokinetic Properties of Antiretroviral And Related Drugs During Pregnancy And Postpartum
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Status : Completed

Botswana Combination Prevention Project (BCPP) / Ya Tsie Study
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Status : Completed

IMPAACT 2010: IMPAACT 2010 Phase III Study of the Virologic Efficacy and Safety of Dolutegravir-Containing versus Efavirenz-Containing Antiretroviral Therapy Regimens in HIV-1-Infected Pregnant Women and their Infants
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Status : Completed

IMPAACT 2008: A Phase I/II Multisite, Randomized, Controlled Study of Monoclonal Antibody VRC01 with Combination Antiretroviral Therapy to Promote Clearance of HIV-1-Infected Cells in Infants
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Status : Completed

COVID-19: An observational cohort of cases treated in Gaborone, Botswana
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Status : Completed

Potlako: A programmatic Multi-Facility Level Intervention to Improve Access to timely Oncology Care in Botswana
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Status : Ongoing

P1093 - Phase I/II, Multi-Centre, Open-Label Pharmacokinetic, Safety, Tolerability and Antiviral Activity of Dolutegravir, a Novel Integrase Inhibitor, in Combination Regimens in HIV-1 Infected Infants, Children and Adolescents
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Status : Ongoing

Improving TB Screening in Pregnant and Postpartum Women Living with HIV in Botswana
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Status : Ongoing

Point-of-Care HIV Testing and Early Dolutegravir Use for Infants
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Status : Ongoing

Evaluating Opportunities to Improve TB and HIV Care for Adolescents in Botswana
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Status : Ongoing

Increasing Access to Multiple Micronutrient Supplementation – A Pilot Intervention at up to 15 Clinics in Botswana
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Status : Ongoing

Botswana Safe Birth Study
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Status : Ongoing

The Botswana Epidemiological ART Treatment Cohort Study 2 (2TheBEAT Cohort Study)
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Status : Ongoing

Iron and Folic acid supplimentation and adverse birth outcomes in Botswana
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Status : Ongoing

The diagnosis and treatment of Chlamydia trachomatis and Neisseria gonorrhoeae in pregnant women to prevent adverse neonatal consequences.
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Status : Ongoing

Dual HIV/syphilis point-of-care testing to improve identification and treatment of syphilis among pregnant women in Gaborone, Botswana
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Status : Ongoing

IMPRINT NIHR Global Health Research Group
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Status : Ongoing

Single, High-dose AmBisome to Reduce Excess mortality from Cryptococcal Meningitis (SHARE-CM)
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Status : Ongoing

Experiences of Infant Feeding Decision-Making among Mothers Living with and without HIV in Botswana
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Status : Ongoing

In Country Evaluation for the ANC panel
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Status : Ongoing

Cellular and humoral immune response in HIV-1-infected children receiving SARS-CoV2-specific mRNA vaccines in Botswana
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Status : Ongoing

Cognitive Testing of a survey instrument to assess sexual practices, behaviours, and health-related outcomes
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Status : Ongoing

Phase I/II Study of the Safety, Tolerability, Acceptability, and Pharmacokinetics of Oral and Long-Acting Injectable Cabotegravir and Rilpivirine in Virologically Suppressed Children Living with HIV-1, Two to Less Than 12 Years of Age
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Status : Ongoing

Doris Duke Study: Adverse Cardiometabolic Impact of Antiretroviral Treatment Regimens Among Pregnant and Post-Partum Women and Their Infants
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Status : Ongoing

Multi-Country Aetiology of Genital Ulcer Study (MAGUS)
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Status : Ongoing

Evaluation of pregnant and breastfeeding women’s preferences and attitudes towards long-acting pre-exposure prophylaxis: A discrete choice experiment. MERCK
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Status : Ongoing

Post abortion care in Botswana: Impact of HIV status on outcomes
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Status : Ongoing

PRomoting Equity for Pregnant Adolescents in REsearch (PREPARE) in Botswana
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Status : Ongoing

Safety, Tolerability, and Impact of Oral TLR8 Agonist Selgantolimod on HBsAg in Participants with Both Chronic Hepatitis B and HIV; v1.0 May 27, 2022; IND #158394; Site 12701/Gaborone
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Status : Ongoing

The FACET Study: Family Dynamics and Child Neurodevelopment in Botswana
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Status : Ongoing

Virologic and Molecular characterization of HIV-1Strains in non-citizens in Botswana
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Status : Ongoing

Evaluating a Group-Based Intervention to Improve Mental Health and ART Adherence Among Youth Living with HIV in Low Resource Settings (IMPAACT 2016)
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Status : Ongoing

Linking HIV Prevention and Postpartum Care: Safety, Efficacy and Feasibility of Cabotegravir-LA PrEP in a High-Risk Breastfeeding Population in Botswana (Tshireletso Study)
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Status : Ongoing

DYNAMICS OF HIV-1 IN RECENTLY DIAGNOSED INDIVIDUALS IN BOTSWANA IN THE ERA OF “TREAT ALL”
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Status : Ongoing

Virologic responses among people with HIV on dolutegravir-based first line therapy in Botswana
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Status : Completed

Optimizing Maternal & Child Health and Development (Monana Ke Isago Study)
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Status : Ongoing

Motsepe Wastewater Project
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Status : Ongoing

Birth Outcomes Surveillance Study: Tsepamo Study
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Status : Ongoing

Aspirin, antenatal micronutrients, and azithromycin (AAA) trial for maximal reduction of preterm birth and related outcomes
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Status : Ongoing

A Randomized, Double-Blinded, Placebo-Controlled Study of the Combination of Two Long-Acting Broadley Neutralizing Antibodies at ART Initiation in Adults Living With HIV-1 in Sub-Saharan Africa (version 1.0 July 20,2023 for site 12701)
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Status : Ongoing

A Phase 4, Open-Label, Rollover Study to Provide Continued Access to Cabotegravir Long-acting Injection and Rilpivirine Long-acting Injection to Participants Living with Human Immunodeficiency Virus Type 1 (HIV-1) Infection Who Participated in Long-acting
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Status : Ongoing

Genomic epidemiology of Treponema pallidum in South Africa and Botswana
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Status : Ongoing

Efficacy of Human Papillomavirus (HPV) Vaccination to Prevent Infection Among Women Living with HIV: A Prospective, Individual, Double-Blind, Randomized Controlled Study (HOPE-II)
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Status : Ongoing

Long-Term Follow-Up of CAB LA for Participants in HPTN 083 and HPTN 084 CAB PrEP Studies at Risk of HIV Acquisition
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Status : Ongoing

A Phase I, Randomized, Placebo-Controlled Study of the Safety, Antiviral & Immunomodulatory Activity of Broadly Neutralizing Antibodies 3BNC117-LS-J and 10-1074-LS-J in Combination in ART-treated Adults in sub-Saharan Africa Living with HIV during a Monit
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Status : Ongoing

HPV Screening and Management Strategies Utilizing Extended Molecular HPV DNA Genotyping and Viral Load in Women Living with HIV
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Status : Ongoing

Equitable access to care for migrants living with HIV in Southern Africa: Lessons learnt from Botswana’s migrant inclusive program
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Status : Ongoing

IMPAACT 2042: Phase I/II Trial to Evaluate the Impact of Three Broadly Neutralizing Antibodies or Analytic Treatment Interruption on Viral Reservoir, Immune Function, and Maintenance of HIV Suppression in Early-Treated Children in Botswana
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Status : Ongoing

A Clinical Trial to Evaluate the Impact of Broadly Neutralizing Antibodies VRC01LS and 10-1074 on Maintenance of HIV Suppression in a Cohort of Early-Treated Children in Botswana (Dual bNAb Treatment in Children)/ Tatelo Study
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Status : Ongoing

Assessment of Proviral Reservoir: Synergistic combination of reporter cell assay and viral diversity
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Status : Ongoing

Early Infant Treatment Study: A Clinical Trial of HIV Positive Infants in Botswana
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Status : Ongoing

Assessment of Proviral Reservoir: Sub study to determine the role of the immune system on the reservoir.
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Status : Ongoing

Point-of-Care HIV Testing and Early Dolutegravir Use for Infants (Moso Study)
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